Assalamualaikum wbt
CBC Why is it important?
1.Because it is the easiest, cheapest, and fastest way of evaluating the
general condition of our body.
2.It helps to suspect any related disorders and if needed, to undergo
further specific test.
1) WBC (white blood
cell) leukocyte count
1. Increase: leucocytosis, agranulocytosis (neu), absolutely lymphocytosis (lym)
1. Increase: leucocytosis, agranulocytosis (neu), absolutely lymphocytosis (lym)
Causes: infection,
inflammation, certain type leukemia
2. Decrease: leucopenia,
neutropenia (neu), lymphopenia (lym)
Causes: effect of certain drugs, bone
marrow diseases, enlarged spleen
2) RBC (red blood cell) erythrocyte count
1. Increase: erythrocytosis
(reactive/tumor)
Causes: reactive in
case of bleeding, hypoxia (COPD), hyperactivity of bone marrow,
post-phlebotomy, altitude sickness, dehydration, tumor:myeloproliferative disorder,
renal cell carcinoma
2. Decrease: anemia
Causes: iron
deficiency, vitamin B12 deficiency, chronic disease: cancer, HIV/AIDS, chronic
inflammatory disease: Crohn’s disease, rheumatoid arthritis, kidney failure,
bone marrow disability (aplastic anemia) due to infection, drugs and autoimmune
diseases, leukaemia, myelodysplasia or myelofibrosis, multiple myeloma,
lymphoma, increase of blood hemolysis, congenital disease: sickle- cell anemia,
thalassemia
3) Hematocrit (Hct)
it shows how much of the total blood volume in the body consists of red blood cells.
it shows how much of the total blood volume in the body consists of red blood cells.
Hemoglobin (Hgb)
Function: transport oxygen and carbon dioxide from and to the lungs
1. Increase: lung diseases,
living at high altitude, excessive production by bone marrow
2. Decrease: anemia-
nutritional deficiency(iron, vitamin B), blood loss, increase cellular
destruction/lysis, failure of blood production in bone marrow
4)
Mean corpuscular volume (MCV)
it shows the average volume of red blood cells. It helps to diagnose cause of anemia.
it shows the average volume of red blood cells. It helps to diagnose cause of anemia.
1. Increase: anemia associated
with deficiency of vitamin B12 or folate, ineffective production in bone marrow
2. Decrease: iron deficiency
anemia
5)
Mean corpuscular hemoglobin (MCH)
it shows the average amount of hemoglobin in the typical red blood cell.
it shows the average amount of hemoglobin in the typical red blood cell.
6) Red cell
distribution width (RDW or RCDW)
get an idea of the shape and size of red blood cells. In this case, “width” refers to a measurement of distribution, not the size of the cells. Liver disease, anemia, nutritional deficiencies, and a number of health conditions could cause high or low RDW results.
get an idea of the shape and size of red blood cells. In this case, “width” refers to a measurement of distribution, not the size of the cells. Liver disease, anemia, nutritional deficiencies, and a number of health conditions could cause high or low RDW results.
7) Platelet count
function: blood clotting, prevent bleeding
function: blood clotting, prevent bleeding
1. Increase: bleeding,
cigarette smoking, excessive production by bone marrow
2. Decrease: premature
destruction state (immune thrombocytopenia), acute blood loss,drug
effects(heparin), infection with sepsis, hypersplenomegaly, bone marrow failure (leukemia , myelofibrosis)
8)
Mean Platelet Volume (MPV)
shows average size of platelets.
shows average size of platelets.
1. Increase: larger platelet -
heart attack or stroke.
2. Decrease: smaller platelets
- bleeding disorder.
Wallahua’lam..
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